Research Journal of Pharmacy and Technology

Hend Y. Younis ¹, Imad A. Thanoon ², Nabeel N. Fadhil ³, Marwan M. Merkhan ⁴

Affiliations
1 Alssalam Teaching Hospital, Ninevah Health Directorate, Mosul,, IQ
2 College of Medicine, University of Mosul, Mosul,, IQ
3 College of Medicine, Ninevah University, Mosul,, IQ
4 College of Pharmacy, Ninevah University, Mosul,, IQ

Abstract

Type 2 diabetes mellitus (T2DM) is an insidious disorder that may progress asymptomatically, leading to secondary complications. Diabetics were found to have a significantly lower zinc level. This study aims to assess the effects of zinc supplementation for eight weeks on glycemic control, serum insulin level, serum C-peptide level, and insulin resistance. Zinc plus metformin using group had a significant decrease in fasting blood glucose level and glycated hemoglobin, as well as a significant increase in serum insulin and C-peptide levels, but no effect on insulin resistance compared to zinc-free metformin group. Comparing the two groups at the end of the study, the combined effect of zinc plus metformin was highly important versus metformin only except for C-peptide and insulin resistance. Zinc levels were significantly elevated and returned to normal in the interventional group, while in the control group, levels were rather decreased.

Keywords

Glycemic, Insulin, Metformin, Zinc, Diabetes.

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Raghad A. Alkhaerow ¹, Shatha H. Mohammad ², Nabeel N. Fadhil ³

Affiliations
1 Nineveh Health Directorate, Mosul,, IQ
2 College of Medicine, University of Mosul,, IQ
3 College of Medicine, Ninevah University, Mosul,, IQ

Abstract

The aim of this study was to investigate the effect of weekly dose of 50.000IU vitamin D for 8 weeks on serum adiponectin level in diabetic patients who have vitamin D deficiency. The study has been included 80 female and male patients with type 2 diabetes mellitus who have vitamin D deficiency were ages range from 25 to 70 years old. The patients have been prepared to have fasting serum adiponectin and vitamin D level tests. After 8 weeks of treatment with vitamin D as an add-on to the conventional anti-diabetic drugs taken up by the patients, there was a highly significant improvement in vitamin D and serum adiponectin level. The mean ±Std. of vitamin D at the base line was 14.76 ±6.02 ng/ml and after 8 weeks' treatment was 42.865 ±12.012 ng/ml. For adiponectin level, the mean ±Std. at the base line and after 8weeks treatment with vitamin D was 7.316 ±1.563 ng/ml, 9.705 ±3.269 ng/ml respectively. As a conclusion, vitamin D level corrected and became in sufficient values after treatment with 50.000IU vitamin D for 8 weeks. Also there is a highly significant improvement in serum adiponectin level after 8 weeks of vitamin D treatment.

Keywords

Vitamin D, Diabetes, Adiponectin, Insulin.

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